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Clinic

At acute development of a paresis or a paralysis of extremities or a separate extremity it is necessary to specify first of all, they are the organic or functional nature. For organic paralyses (paresises) changes of reflexes, occurrence of pathological symptoms, depression or muscle tone rising are characteristic not only obezdvizhen-nost or delicacy of extremities, but also. Paralyses and the paresises of the central parentage arising at lesions of the central impellent neurone (ways), are accompanied by a hyperreflexia, a muscular hypertonia and occurrence of pathological symptoms (Babinsky, or other), and also are quite often combined with other signs of an organic lesion of nervous system (an alalia) It is necessary to remember, that at acute development of the central paralysis (a hematencephalon or a craniocerebral trauma) originally the muscle tone can be lowered, and reflexes are lowered or lost. Paralyses and paresises arise at lesions of a peripheric impellent neurone (forward horns of a spinal cord, forward roots, peripheric nerves), are characterised by a muscular atony, an atrophy and an areflexia. Quite often thus pains and sensitivity disorders are observed. Functional paralyses of extremities can arise at a hysteria. At hysterical paralyses periosteal and reflexes remain, pathological reflexes are absent, and a muscle tone, as a rule, does not change. Known help for definition of the nature of the central paralysis is specification of localisation of pathological process. So, the paresis or a paralysis of one extremity testifies to process localisation in an impellent zone of a cortex of an opposite hemicerebrum. The hemiplegia specifies that process is more deeply (in an internal capsule or to it departments). At a combination of a paresis or a paralysis of extremities on one party with a peripheric paresis or a paralysis of any cranial nerve of an opposite side it is necessary to think of a lesion of a trunk of a brain. In such cases the organic nature of process is doubtless. The paresis or paralysis of an arm and opposite foot (two-dimensional paralysis) testifies to one-focal process on border between oblong and a spinal cord. If at the patient the central paresis or a paralysis of an arm and a foot on one party develops, and signs of a lesion of cranial nerves are absent, it is possible to suspect a lesion ways in spinal cord department. The peripheric paresis or paralysis of an arm and the central paresis or paralysis of the foot with the same name arise at a partial lesion of a spinal cord at level of a cervical thickening. The central paralysis of a foot can be caused a lesion of the top departments of an opposite central gyrus, presence of the small centre in a radiate crown or in the field of a lateral column of a spinal cord from top to bottom from a cervical thickening. The foot flaccid paralysis develops at a hemilesion of a lumbar thickening, and also trunks lumbar and plexuses. Occurrence of flaccid paralyses of separate muscles of feet or their muscular groups can be caused a selective lesion of motor-neurones of forward horns of a spinal cord in the field of a lumbar thickening (for example, at a poliomyelitis) or separate nervous trunks (femoral, sciatic or their branches). At hysterical paralyses signs of a focal lesion are absent, that is why it is not obviously possible to tell, in connection with what lesion of a site of nervous system they have arisen. Acute disturbances of a cerebral circulation (a brain infarct, a hematencephalon, etc.), tumours, encephalitises, a multiple sclerosis, , a cataplexy, neuritises or polyneurites happen the reason of paresises and paralyses more often, etc. Rendering assistance. Depends both on features of pathological process, and from character of a paresis or a paralysis (peripheric, central, hysterical, etc.).


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Clinic. The myasthenia concerns nervously-muscular diseases and is shown by delicacy and pathological fatigability of striated muscles. About 60 % of cases of a myasthenia it is accompanied by a pathology of a thymic gland - a leading organ of an immunogenesis. In blood the hypoglycaemia becomes perceptible. Muscular delicacy accrues at an exercise stress and decreases after rest or introduction to prose-rina. Disease begins at the age of 20-30 years. Women is more often are ill. The earliest and constant symptom (about 70 %) is delicacy of oculomotor muscles in this connection arise a ptosis, a diplopia. In other cases (about 20 %) initial symptoms of illness are shown by delicacy and pathological fatigability of muscles of a larynx, a pharynx and the tongue, speech leading to disturbances, mastications and swallowing. Much less often the specified changes arise in muscles of a trunk and extremities. At the generalised form of a myasthenia muscles, are amazed with cranial and spinal nerves, the paresis of respiratory muscles, muscular atrophies join. and periosteal reflexes do not change. The hypomyotonia can be observed. For a myasthenia, especially in an initial stage of disease, are characteristic dynamism of symptoms within days. The paresis of muscles is more expressed to the extremity of day and after an exercise stress. At patients with serious forms of a myasthenia there can suddenly come sharp intensifying of muscular delicacy, disturbance of breath and warm activity (a myasthenic crisis). Rendering assistance. The myasthenic crisis is stopped by intravenous or hypodermic introduction of 0,05 of a solution of a neostigmine methylsulfate of 0,5-1 ml with its repeated injections, ambenonium chloride intake on 0,001-0,005 2-3 times a day after meal. If a crisis serious, connect apparatus artificial breath. The basic method of treatment is regular reception anti-holinesteraznyh preparations (a neostigmine methylsulfate, Bromidum, oksa-zil, Galantaminum, Physostigminum). A neostigmine methylsulfate prescribe for intake in tablets (0,015 2-3 times a day) and for injections (1 ml of 0,05 of a solution). Entered , it renders effect in 15-20 minutes In serious cases to patients give on 2-4 tablets through everyone 1-2. Bromidum (tablets on 0,06) operates more strongly on muscles, with cranial nerves. Accepted inside, it has an effect during 6-8 . The preparation is good for combining with a neostigmine methylsulfate. The ambenonium chloride (tablets on 0,001-0,01) is more toxic, than a neostigmine methylsulfate and Mestinonum (Kalyminum). It is prescribed inside the adult on 0,06 1-3 times a day, subcutaneously or intramusculary by 0,4-1 ml of 0,5 of a solution (2 5 mg). A dose select individually depending on gravity and shipping. Galantaminum enter subcutaneously (0,5-1 ml of a solution of 1) Treatment preparations combine with application of ephedrine (0,025), Sodium chloridum potassium (10 % a solution), Aldactonum (0,025), vitamins and fortifying agents. At detection of a pathology of a thymic gland prescribe a roentgenotherapy to its area separately or together with a thymectomy. The big doses preparations can cause the cholinergic crisis reminding the myasthenic. However unlike the last the cholinergic crisis develops gradually: muscular delicacy accrues, amplify or there are parkway symptoms, breath is upset, pupils are narrowed. Introduction preparations worsens a condition even more. There is a headache, drowsiness, vomiting, a hypersalivation, a sweating, abdominal pains, diarrhoeia, fascicular twitchings of muscles, a tremor, sometimes cramps. At a cholinergic crisis of the patient .on the PULMONARY ventilation. To cancel preparations and to enter subcutaneously 0,5-1 ml of 0,1 % of a solution of atropine. In case of need atropine enter repeatedly. Subcutaneously enter Dipiroxinum (1 ml of 15 % of a solution), Amizylum (0,001-0,002 3-5 times a day. It is necessary to observe of an involution of symptoms and in due time to connect preparations.